Abstract
Novel racemic, D- and L-beta-dioxolane N4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antiviral Agents / chemical synthesis
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Antiviral Agents / chemistry
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Antiviral Agents / pharmacology*
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Cell Line, Tumor
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Cytosine / analogs & derivatives
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Cytosine / chemical synthesis
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Cytosine / pharmacology*
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Dioxolanes / chemical synthesis
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Dioxolanes / chemistry
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Dioxolanes / pharmacology*
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Hepatitis B virus*
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Humans
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Nucleosides / chemical synthesis
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Nucleosides / chemistry
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Nucleosides / pharmacology*
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Virus Replication / drug effects*
Substances
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Antiviral Agents
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Dioxolanes
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Nucleosides
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Cytosine
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formal glycol