Abstract
Four flavonoids with 2',4'-di-oxygenated B-rings, cochinchinol A (1), cochinchinol B (2), (2R,3R)-4',7-dihydroxy-2',5-dimethoxydihydroflavonol (3), 4',7-dihydroxy-2',5-dimethoxyflavonol (4), along with 11 known compounds, were isolated from an ethanolic extract of the roots of Cudrania cochinchinensis. Their structures were elucidated by chemical and spectroscopic methods. Cochinchinol A (1) and cochinchinol B (2) have two hitherto unprecedented flavonol salt structures in natural product chemistry. Cytotoxic activities were evaluated against several different cell lines.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology
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Drug Screening Assays, Antitumor
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Flavonoids / chemistry*
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Flavonoids / isolation & purification
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Flavonoids / pharmacology
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Humans
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Magnesium / chemistry
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Moraceae / chemistry*
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Plant Roots / chemistry*
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Plants, Medicinal / chemistry
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Salts / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Ultraviolet
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Flavonoids
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Salts
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cochinchinol A
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cochinchinol B
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Magnesium