Comparative genomic hybridization of ectopic pregnancies that fail methotrexate therapy

Laurie Jane McKenzie; Hala El-Zimaity; Stephan Krotz; Rodolfo Laucirica; Sandra Carson; John E Buster

doi:10.1016/j.fertnstert.2005.04.064

Comparative genomic hybridization of ectopic pregnancies that fail methotrexate therapy

Fertil Steril. 2005 Nov;84(5):1517-9. doi: 10.1016/j.fertnstert.2005.04.064.

Authors

Laurie Jane McKenzie¹, Hala El-Zimaity, Stephan Krotz, Rodolfo Laucirica, Sandra Carson, John E Buster

Affiliation

¹ Reproductive Endocrinology and Infertility Division, Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA. [email protected]

PMID: 16275259
DOI: 10.1016/j.fertnstert.2005.04.064

Abstract

Ectopic pregnancies that fail methotrexate therapy are predominantly euploid by comparative genomic hybridization (CGH). This feasibility study also confirms that formalin-fixed paraffin-embedded gestational tissue can successfully undergo CGH.

Publication types

Comparative Study

MeSH terms

Female
Humans
Methotrexate / therapeutic use*
Nucleic Acid Hybridization / methods
Pregnancy
Pregnancy, Ectopic / drug therapy*
Pregnancy, Ectopic / genetics*
Retrospective Studies
Treatment Failure

Substances

Methotrexate