Abstract
Vaccination of cats with fowlpox virus expressing the avian influenza (AI) virus H5 hemagglutinin gene (TROVAC AI) resulted in detectable hemagglutination inhibition (HI) antibody responses to the homologous A/Turkey/Ireland/1378/83 (H5N8) (A/tky/Ire/83) AI virus antigen. The HI antibody responses to heterologous A/Chicken/Indonesia/7/03 (H5N1) (A/ck/Indonesia/03) AI virus antigen were also detected in all vaccinated cats, but only after booster vaccinations. The vaccine described in this study and other poxvirus-vectored vaccines may be of value for the prophylaxis of AI virus-associated morbidity and mortality in mammals.
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Antibodies, Viral / blood
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Cat Diseases / immunology
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Cat Diseases / prevention & control
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Cat Diseases / virology
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Cats
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Fowlpox virus / immunology*
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Hemagglutination Inhibition Tests
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Hemagglutinin Glycoproteins, Influenza Virus / biosynthesis*
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Hemagglutinin Glycoproteins, Influenza Virus / genetics*
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Hemagglutinin Glycoproteins, Influenza Virus / immunology
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Humans
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Influenza Vaccines / administration & dosage
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Influenza Vaccines / immunology*
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Influenza, Human / prevention & control
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Influenza, Human / virology
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Organisms, Genetically Modified / immunology
Substances
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Antibodies, Viral
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Hemagglutinin Glycoproteins, Influenza Virus
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Influenza Vaccines
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hemagglutinin, avian influenza A virus