Tissue segmentation and classification of MRSI data using canonical correlation analysis

Magn Reson Med. 2005 Dec;54(6):1519-29. doi: 10.1002/mrm.20710.

Abstract

In this article an accurate and efficient technique for tissue typing is presented. The proposed technique is based on Canonical Correlation Analysis, a statistical method able to simultaneously exploit the spectral and spatial information characterizing the Magnetic Resonance Spectroscopic Imaging (MRSI) data. Recently, Canonical Correlation Analysis has been successfully applied to other types of biomedical data, such as functional MRI data. Here, Canonical Correlation Analysis is adapted for MRSI data processing in order to retrieve in an accurate and efficient way the possible tissue types that characterize the organ under investigation. The potential and limitations of the new technique have been investigated by using simulated as well as in vivo prostate MRSI data, and extensive studies demonstrate a high accuracy, robustness, and efficiency. Moreover, the performance of Canonical Correlation Analysis has been compared to that of ordinary correlation analysis. The test results show that Canonical Correlation Analysis performs best in terms of accuracy and robustness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Artificial Intelligence
  • Humans
  • Image Enhancement / methods*
  • Image Interpretation, Computer-Assisted / methods*
  • Imaging, Three-Dimensional / methods*
  • Information Storage and Retrieval / methods
  • Magnetic Resonance Imaging / instrumentation
  • Magnetic Resonance Imaging / methods*
  • Magnetic Resonance Spectroscopy / instrumentation
  • Magnetic Resonance Spectroscopy / methods*
  • Male
  • Pattern Recognition, Automated / methods*
  • Phantoms, Imaging
  • Prostatic Neoplasms / pathology*
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Statistics as Topic