Fatal natural killer cell lymphoma arising in a patient with a crop of Epstein-Barr virus-associated disorders

Eur J Dermatol. 2005 Nov-Dec;15(6):503-6.

Abstract

Natural killer (NK) lymphoma in Asia is frequently associated with latent Epstein-Barr (EBV) infection. Unlike the adult cases, EBV-associated NK/T cell lymphomas in children are often preceded by various EBV-related disorders, including chronic active EBV infection (CAEBV), hypersensitivity to mosquito bites (HMB), virus-associated haemophagocytic syndrome (VAHS), and hydroa vacciniforme (HV)-like eruptions. Here, we report a 14-year-old Japanese girl who sequentially developed all the symptoms related to EBV-associated NK/T cell lymphoproliferative disorders in a 12-year clinical course. Our observations confirm the spectrum of EBV-associated cutaneous disorders and indicate the importance of long-term follow-up.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child, Preschool
  • Epstein-Barr Virus Infections / complications*
  • Female
  • Follow-Up Studies
  • Humans
  • Killer Cells, Natural*
  • Lymphoma / etiology*