Relationship between 5,10-methylenetetrahydrofolate reductase C677T gene polymorphism and methotrexate related toxicity in patients with autoimmune diseases receiving folic acid supplementation

Ann Rheum Dis. 2005 Dec;64(12):1791-2. doi: 10.1136/ard.2005.037218.
No abstract available

Publication types

  • Letter

MeSH terms

  • 5,10-Methylenetetrahydrofolate Reductase (FADH2) / genetics*
  • Adult
  • Aged
  • Aged, 80 and over
  • Antirheumatic Agents / adverse effects
  • Autoimmune Diseases / drug therapy*
  • Dietary Supplements
  • Drug Interactions
  • Female
  • Folic Acid / therapeutic use*
  • Humans
  • Male
  • Methotrexate / adverse effects*
  • Middle Aged
  • Polymorphism, Genetic*
  • Retrospective Studies
  • Rheumatic Diseases / drug therapy

Substances

  • Antirheumatic Agents
  • Folic Acid
  • 5,10-Methylenetetrahydrofolate Reductase (FADH2)
  • Methotrexate