Regiospecific and stereoselective syntheses of (+/-)-reserpine and (-)-reserpine

Gilbert Stork; Peng Cho Tang; Michael Casey; Burton Goodman; Masahiro Toyota

doi:10.1021/ja055744x

Regiospecific and stereoselective syntheses of (+/-)-reserpine and (-)-reserpine

J Am Chem Soc. 2005 Nov 23;127(46):16255-62. doi: 10.1021/ja055744x.

Authors

Gilbert Stork¹, Peng Cho Tang, Michael Casey, Burton Goodman, Masahiro Toyota

Affiliation

¹ Department of Chemistry, Columbia University, New York, New York 10027, USA. [email protected]

PMID: 16287318
DOI: 10.1021/ja055744x

Abstract

Full details of three approaches to an entirely regio- and stereoselective synthesis of the well-known target reserpine are described, culminating in a total synthesis which efficiently meets these requirements.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cyclization
Molecular Structure
Reserpine / chemical synthesis*
Reserpine / chemistry*
Stereoisomerism

Substances

Reserpine