Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic

Jessica M Davis; Anh Truong; Andrew D Hamilton

doi:10.1021/ol0521228

Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic

Org Lett. 2005 Nov 24;7(24):5405-8. doi: 10.1021/ol0521228.

Authors

Jessica M Davis¹, Anh Truong, Andrew D Hamilton

Affiliation

¹ Department of Chemistry, Yale University, P.O. Box 20810, New Haven, Connecticut 06511, USA.

PMID: 16288517
DOI: 10.1021/ol0521228

Abstract

[reaction: see text] A terpyridine scaffold has been designed as an alpha-helix mimetic. A facile synthesis of the ortho-functionalized 2,3'-oligopyridine has been accomplished using sequential Bohlmann-Rahtz heteroannulation reactions.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Catalysis
Molecular Conformation
Molecular Mimicry
Molecular Structure
Palladium / chemistry
Pyridines / chemical synthesis*
Pyridines / chemistry*

Substances

2,3',6',3''-terpyridine
Pyridines
Palladium

Grants and funding

GM69850/GM/NIGMS NIH HHS/United States