A stereochemically well-defined rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones

Daljit S Matharu; David J Morris; Aparecida M Kawamoto; Guy J Clarkson; Martin Wills

doi:10.1021/ol052559f

A stereochemically well-defined rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones

Org Lett. 2005 Nov 24;7(24):5489-91. doi: 10.1021/ol052559f.

Authors

Daljit S Matharu¹, David J Morris, Aparecida M Kawamoto, Guy J Clarkson, Martin Wills

Affiliation

¹ Asymmetric Catalysis Group, Department of Chemistry, University of Warwick, Coventry, UK.

PMID: 16288538
DOI: 10.1021/ol052559f

Abstract

[reaction: see text] A rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones has been designed. The incorporation of a tethering group between the diamino group and the cyclopentadienyl unit provides extra stereochemical rigidity. The catalyst is capable of enantioselective reduction of a range of ketones in excellent ee using formic acid/triethylamine as both the solvent and the reducing agent.