Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

Suresh Awale; Eduardo M N Nakashima; Surya K Kalauni; Yasuhiro Tezuka; Yukiko Kurashima; Jie Lu; Hiroyasu Esumi; Shigetoshi Kadota

doi:10.1016/j.bmcl.2005.10.046

Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

Bioorg Med Chem Lett. 2006 Feb;16(3):581-3. doi: 10.1016/j.bmcl.2005.10.046. Epub 2005 Nov 8.

Authors

Suresh Awale¹, Eduardo M N Nakashima, Surya K Kalauni, Yasuhiro Tezuka, Yukiko Kurashima, Jie Lu, Hiroyasu Esumi, Shigetoshi Kadota

Affiliation

¹ Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.

PMID: 16288865
DOI: 10.1016/j.bmcl.2005.10.046

Abstract

The CH(2)Cl(2)-soluble extract of Angelica pubescens was found to kill PANC-1 cancer cells preferentially under nutrition starvation at a concentration of 50 microg/ml, with virtually no cytotoxicity under nutrient-rich conditions. Further bioassay-guided fractionation and isolation led to the isolation of a novel compound named angelmarin as the primary compound responsible for the preferential cytotoxicity; the compound exhibited 100% preferential cytotoxicity against PANC-1 cells at a concentration of 0.01 microg/ml.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angelica / chemistry*
Antineoplastic Agents / isolation & purification
Antineoplastic Agents / pharmacology*
Cell Survival / drug effects
Coumarins / isolation & purification*
Coumarins / pharmacology
Humans
Pancreatic Neoplasms / pathology
Plant Extracts / chemistry*
Plant Extracts / isolation & purification
Plant Extracts / pharmacology
Plants, Medicinal
Time Factors
Tumor Cells, Cultured

Substances

Antineoplastic Agents
Coumarins
Plant Extracts
angelmarin