A theoretical model was developed to simulate the coupling between the adhered leukocyte and blood flow. Methods of computational fluid dynamics (CFD) were introduced to analyze the distributions of the shear stress and the pressure on the cell surface. Meanwhile, the hemodynamical parameters were measured with laser Doppler velocimetry. The results showed that the deformation index of the leukocyte was increased with initial contact angle and Reynolds number. The blood flow induced the redistributions of the shear stress and pressure on the surface of the cell, but the maximum shear stress was on the top point of the cell. It suggests that the non-uniform distribution of shear stress on the cell surface may play a particular role in the change of cell shape and functions.