Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens

J M Boulter; B K Jakobsen

doi:10.1111/j.1365-2249.2005.02929.x

Stable, soluble, high-affinity, engineered T cell receptors: novel antibody-like proteins for specific targeting of peptide antigens

Clin Exp Immunol. 2005 Dec;142(3):454-60. doi: 10.1111/j.1365-2249.2005.02929.x.

Authors

J M Boulter¹, B K Jakobsen

Affiliation

¹ Department of Medical Biochemistry and Immunology, Henry Wellcome Building, School of Medicine, Cardiff University, Heath Park, UK. [email protected]

Abstract

The recent development of T cell receptor phage display opens up the possibility of engineering human T cell receptors with antibody-like binding properties for cell-surface peptide antigens. In this review we briefly discuss recent developments in molecular targeting of peptide antigens. We then discuss potential clinical applications of engineered high-affinity T cell receptors in autoimmunity and cancer.

Publication types

Review

MeSH terms

Antibodies / immunology*
Antibodies, Monoclonal / immunology
Antibody Affinity / immunology
Antigens / immunology*
Autoimmune Diseases / immunology
Autoimmune Diseases / therapy
Bacteriophages / immunology
Cell Membrane / immunology
Humans
Immunotherapy / methods
Major Histocompatibility Complex / immunology
Models, Immunological
Neoplasms / immunology
Neoplasms / therapy
Peptides / immunology*
Receptors, Antigen, T-Cell / immunology*

Substances

Antibodies
Antibodies, Monoclonal
Antigens
Peptides
Receptors, Antigen, T-Cell