Abstract
The spread of multiresistant Staphylococcus and Enterococcus strains required the development of new drugs. Linezolid is the first molecule of a new antibiotic family, oxazolidinones, with an original mechanism of action. In this general review, the authors first present its antibacterial activity, its pharmacokinetic properties, its therapeutic uses in serious Gram-positive infections, pneumonia, skin and soft tissue infections, and also in other indications. They then explain the rules for administration and tolerability.
MeSH terms
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Acetamides / pharmacokinetics
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Acetamides / therapeutic use*
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Anti-Infective Agents / pharmacokinetics
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Anti-Infective Agents / therapeutic use*
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Enterococcus / drug effects*
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Gram-Positive Bacterial Infections / drug therapy*
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Humans
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Linezolid
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Oxazolidinones / pharmacokinetics
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Oxazolidinones / therapeutic use*
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Protein Synthesis Inhibitors / pharmacokinetics
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Protein Synthesis Inhibitors / therapeutic use*
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Staphylococcus / drug effects*
Substances
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Acetamides
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Anti-Infective Agents
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Oxazolidinones
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Protein Synthesis Inhibitors
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Linezolid