Abstract
As part of a study into antimycobacterial compounds a set of phenolic N1-benzylidene-pyridinecarboxamidrazones was prepared and evaluated. This report describes the unexpected discovery of a potent compound with a pronounced selectivity for Gram-positive bacteria over Gram-negative micro-organisms. In addition, this compound is active against various drug-resistant Gram-positive bacteria.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Drug Resistance, Bacterial
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Gram-Positive Bacteria / drug effects*
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Humans
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Leukocytes / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Pyridines / chemical synthesis
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Pyridines / chemistry
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Pyridines / pharmacology*
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Pyridines