Abstract
Most of the SARS-CoV-infected patients spontaneously recovered without clinical intervention while a small percentage succumbed to the disease. Here, we characterized temporal changes in N protein-specific and S glycoprotein-specific neutralizing antibody (Nab) responses in infected patients who have either recovered from or succumbed to SARS-CoV infection. Recovered patients were found to have higher and sustainable levels of both N protein-specific and S glycoprotein-specific Nab responses, suggesting that antibody responses likely play an important role in determining the ultimate disease outcome of SARS-CoV-infected patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Viral / blood
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Antibodies, Viral / immunology*
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Coronavirus Nucleocapsid Proteins
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Disease Progression
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Humans
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Membrane Glycoproteins / immunology
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Neutralization Tests
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Nucleocapsid Proteins / immunology
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Severe Acute Respiratory Syndrome / immunology*
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Severe Acute Respiratory Syndrome / physiopathology
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Severe acute respiratory syndrome-related coronavirus / immunology*
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins / immunology
Substances
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Antibodies, Viral
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Coronavirus Nucleocapsid Proteins
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Membrane Glycoproteins
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Nucleocapsid Proteins
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins
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spike glycoprotein, SARS-CoV