Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives

Eur J Med Chem. 2006 Jan;41(1):71-9. doi: 10.1016/j.ejmech.2005.10.011. Epub 2005 Nov 21.

Abstract

Some novel aminosubstituted azapyranoxanthenones, bearing structural similarity to the acridone alkaloid acronycine, have been designed and synthesized. Their in vitro cytotoxicities against the murine L1210 leukemia and the human solid tumor HT-29 cell lines have been investigated. Their eventual selective effect on a phase of the cell cycle was evaluated, using HT-29 cells. A number of the new derivatives exhibited interesting cytotoxic activity against the human solid tumor cell line.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acronine / analogs & derivatives*
  • Acronine / chemical synthesis
  • Acronine / pharmacology
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Cycle / drug effects
  • Cell Proliferation / drug effects*
  • Drug Design
  • Drug Screening Assays, Antitumor
  • HT29 Cells / drug effects
  • Humans
  • Inhibitory Concentration 50
  • Leukemia L1210 / drug therapy
  • Mice
  • Molecular Structure
  • Structure-Activity Relationship
  • Xanthenes* / chemical synthesis
  • Xanthenes* / chemistry
  • Xanthenes* / pharmacology

Substances

  • Antineoplastic Agents
  • Xanthenes
  • Acronine