VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid

Spyros Pournaras; Alexandros Ikonomidis; Leonidas S Tzouvelekis; Despoina Tokatlidou; Nicholas Spanakis; Antonios N Maniatis; Nicholas J Legakis; Athanassios Tsakris

doi:10.1128/AAC.49.12.5153-5156.2005

VIM-12, a novel plasmid-mediated metallo-beta-lactamase from Klebsiella pneumoniae that resembles a VIM-1/VIM-2 hybrid

Antimicrob Agents Chemother. 2005 Dec;49(12):5153-6. doi: 10.1128/AAC.49.12.5153-5156.2005.

Authors

Spyros Pournaras¹, Alexandros Ikonomidis, Leonidas S Tzouvelekis, Despoina Tokatlidou, Nicholas Spanakis, Antonios N Maniatis, Nicholas J Legakis, Athanassios Tsakris

Affiliation

¹ Department of Microbiology, Medical School, University of Thessaly, Larissa, Greece. [email protected]

Abstract

A transferable plasmid from Klebsiella pneumoniae carried a class 1 integron containing bla(VIM-12), a novel bla(VIM)-type gene, flanked by two copies of aacA7. bla(VIM-12) was clustered between bla(VIM-1) and bla(VIM-2) and differed from bla(VIM-1) by 18 nucleotides that were all located at the 3' end and matched the corresponding nucleotides in bla(VIM-2). The bla(VIM-12)-associated 59-base element was identical to that described in bla(VIM-2) alleles.

MeSH terms

Alleles
Drug Resistance, Multiple, Bacterial / genetics*
Klebsiella pneumoniae / enzymology*
Klebsiella pneumoniae / genetics
Molecular Sequence Data
Plasmids / genetics*
beta-Lactamases / genetics*

Substances

VIM-1 metallo-beta-lactamase
beta-lactamase bla(vim-2)
beta-Lactamases
beta-lactamase VIM-12, Klebsiella pneumoniae

Associated data

GENBANK/DQ143913