Abstract
The glycosyltransferase enzyme LgtA, derived from the bacterial pathogen Neisseria meningitidis, was utilised in the chemo-enzymatic synthesis of a trisaccharide-linked endomorphin peptide drug candidate.
MeSH terms
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Bacterial Proteins / chemistry*
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Base Sequence
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Carbohydrate Sequence
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DNA Primers
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DNA, Recombinant
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Drug Delivery Systems*
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Electrophoresis, Polyacrylamide Gel
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Glycosylation
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Molecular Sequence Data
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N-Acetylglucosaminyltransferases / chemistry*
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Peptides / administration & dosage
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Peptides / chemistry*
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Spectrometry, Mass, Electrospray Ionization
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Trisaccharides / administration & dosage
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Trisaccharides / chemistry*
Substances
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Bacterial Proteins
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DNA Primers
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DNA, Recombinant
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Peptides
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Trisaccharides
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LgtA protein, bacteria
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N-Acetylglucosaminyltransferases