MLL gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemia

Leukemia. 2006 Jan;20(1):179-82. doi: 10.1038/sj.leu.2404031.

Authors

R W Stam, I Hubeek, M L den Boer, J G C A M Buijs-Gladdines, U Creutzig, G J L Kaspers, R Pieters

PMID: 16307022
DOI: 10.1038/sj.leu.2404031

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Cell Proliferation / drug effects
Cytarabine / therapeutic use*
Drug Resistance, Neoplasm / genetics*
Drug Screening Assays, Antitumor
Gene Rearrangement*
Histone-Lysine N-Methyltransferase
Humans
In Vitro Techniques
Leukemia, Monocytic, Acute / drug therapy*
Leukemia, Myelomonocytic, Acute / drug therapy*
Models, Biological
Myeloid-Lymphoid Leukemia Protein / drug effects
Myeloid-Lymphoid Leukemia Protein / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*

Substances

KMT2A protein, human
Cytarabine
Myeloid-Lymphoid Leukemia Protein
Histone-Lysine N-Methyltransferase