Effects of preparations modifying Th1/Th2 ratio on the incidence of clinical variants of chronic graft-versus-host reaction

O T Kudaeva; E V Goiman; A P Lykov; O P Kolesnikova; V A Kozlov

doi:10.1007/s10517-005-0484-y

Effects of preparations modifying Th1/Th2 ratio on the incidence of clinical variants of chronic graft-versus-host reaction

Bull Exp Biol Med. 2005 Sep;140(3):338-40. doi: 10.1007/s10517-005-0484-y.

Authors

O T Kudaeva¹, E V Goiman, A P Lykov, O P Kolesnikova, V A Kozlov

Affiliation

¹ Institute of Clinical Immunology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. [email protected]

PMID: 16307053
DOI: 10.1007/s10517-005-0484-y

Abstract

Induction of chronic graft-versus-host reaction in a semiallogenic DBA/2- (DBA/2xC57Bl/6) F1 system leads to the development of Th1- or Th2-dependent immunopathologies. Modification of the Th1/Th2 ratio during induction with preparations acting on the immune system cells via different mechanisms and shifting the Th1/Th2 balance towards Th2 (bisphenol A, pentoxifylline, muramyl dipeptide) increases the incidence of Th2-dependent autoimmune lupus-like glomerulonephritis.

MeSH terms

Acetylmuramyl-Alanyl-Isoglutamine / pharmacology
Animals
Anti-Glomerular Basement Membrane Disease / etiology
Anti-Glomerular Basement Membrane Disease / immunology
Benzhydryl Compounds
Female
Glomerulonephritis / immunology
Graft vs Host Reaction / immunology*
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
Pentoxifylline / pharmacology
Phenols / pharmacology
Proteinuria / chemically induced
Th1 Cells / immunology*
Th2 Cells / immunology*

Substances

Benzhydryl Compounds
Phenols
Acetylmuramyl-Alanyl-Isoglutamine
bisphenol A
Pentoxifylline