Abstract
PAMAM dendrimer-RGD-4C peptide conjugate was synthesized and in vitro targeting efficacy to integrin receptor expressing cells was studied by flow cytometry and confocal microscopy.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Angiogenesis Inhibitors / chemistry*
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Angiogenesis Inhibitors / metabolism*
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Animals
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Cell Line
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Dendrimers
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Drug Delivery Systems / methods*
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Humans
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Integrins / metabolism
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Mice
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Molecular Structure
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Neoplasms / blood supply*
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Neoplasms / drug therapy*
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Neovascularization, Pathologic
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Oligopeptides / chemistry
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Oligopeptides / metabolism*
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Polyamines / chemistry
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Polyamines / metabolism*
Substances
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Angiogenesis Inhibitors
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Dendrimers
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Integrins
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Oligopeptides
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PAMAM Starburst
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Polyamines
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arginyl-glycyl-aspartic acid