A microarray data analysis framework for postmortem tissues

Edmund S Jackson; Matt T Wayland; William Fitzgerald; Sabine Bahn

doi:10.1016/j.ymeth.2005.09.006

A microarray data analysis framework for postmortem tissues

Methods. 2005 Nov;37(3):247-60. doi: 10.1016/j.ymeth.2005.09.006.

Authors

Edmund S Jackson¹, Matt T Wayland, William Fitzgerald, Sabine Bahn

Affiliation

¹ Signal Processing Laboratory, Department of Engineering, University of Cambridge, UK.

PMID: 16308154
DOI: 10.1016/j.ymeth.2005.09.006

Abstract

This paper will give a complete methodological approach to the processing of oligonucleotide microarray data from postmortem tissue, particularly brain matter. Attention will be drawn to each of the important stages in the process; specifically the quality control, gene expression value calculation, multiple hypothesis testing and correlation analyses. We shall initially discuss the theoretical foundations of each individual method and subsequently apply the ensemble to a sample data set to illustrate and visualise important points.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Autopsy
Computational Biology / methods*
Diagnosis*
Gene Expression Profiling / methods
Models, Biological
Oligonucleotide Array Sequence Analysis / methods*
Quality Control