Abstract
Five new tetrahydrofuran lignans (1-5), accompanied by four known compounds, were isolated from the ethyl acetate extract of Peperomia dindygulensis. Structures were elucidated mainly using 1D NMR, 2D NMR, and mass spectroscopic studies. The relative configurations of 1-5 were determined by NOE correlations. Several of the compounds showed weak growth inhibitory activity against three cell lines (WI-38, VA-13, and HepG2). Compound 5 exhibited stronger MDR (multidrug resistance) reversal activity than verapamil at 2.5 microg/mL in a cellular calcein accumulation assay. Compounds 4 and 5 showed weak inhibitory activity against induction of the intercellular adhesion molecule-1 (ICAM-1) in anti-inflammatory activity experiments.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology
-
Antineoplastic Agents, Phytogenic / chemistry
-
Antineoplastic Agents, Phytogenic / isolation & purification*
-
Antineoplastic Agents, Phytogenic / pharmacology
-
Drug Screening Assays, Antitumor
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Furans / chemistry
-
Furans / isolation & purification*
-
Furans / pharmacology
-
Humans
-
Intercellular Adhesion Molecule-1 / biosynthesis
-
Intercellular Adhesion Molecule-1 / drug effects
-
Lignans / chemistry
-
Lignans / isolation & purification*
-
Lignans / pharmacology
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Peperomia / chemistry*
-
Plants, Medicinal / chemistry*
-
Tumor Cells, Cultured
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Antineoplastic Agents, Phytogenic
-
Drugs, Chinese Herbal
-
Furans
-
Lignans
-
Intercellular Adhesion Molecule-1
-
tetrahydrofuran