Is primidone the drug of choice for epileptic patients with QT-prolongation? A comprehensive analysis of literature

Seizure. 2006 Jan;15(1):64-6. doi: 10.1016/j.seizure.2005.10.002. Epub 2005 Nov 22.

Abstract

Sudden unexplained/unexpected death (SUDEP) in epilepsy is a major cause of death accounting for 7-17% of the mortality among epileptic patients. Prolongation of QT-interval has been issued as a major mechanism in SUDEP since it is associated with fatal cardiac arrhythmias. This condition may be further precipitated by anti-epileptic treatment. Despite thorough literature research, we did not find any reports suggesting that primidone is responsible for QT-prolongation. On the contrary, all the retrieved reports addressed that the drug shortened QT-interval and corrected signs and symptoms of the underlying disease.

Publication types

  • Review

MeSH terms

  • Anticonvulsants / adverse effects*
  • Anticonvulsants / therapeutic use
  • Death, Sudden / etiology*
  • Electrocardiography / drug effects
  • Epilepsy / drug therapy*
  • Epilepsy / mortality
  • Humans
  • Long QT Syndrome / chemically induced*
  • Primidone / adverse effects*
  • Primidone / therapeutic use

Substances

  • Anticonvulsants
  • Primidone