A simple explanation of the electrostatics of the B-to-Z transition of DNA

Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5740-3. doi: 10.1073/pnas.89.13.5740.

Abstract

Whereas the phosphates of B-DNA jut out into the solution, those of Z-DNA, being closer to DNA matter, are less subject to electrostatic screening by counterions. We present simple planar models of B- and Z-DNA that reflect these geometric features. The ionic strength dependence of the difference in the Poisson-Boltzmann electrostatic free energy of the models agrees with that measured by Pohl [Pohl, F. M. (1983) Cold Spring Harbor Symp. Quant. Biol. 47, 113-118]. This indicates that the electrostatics of the B-to-Z transition are primarily controlled by a qualitative geometrical difference and not by details of the DNA geometry or by complex electrostatic properties of the ionic solution.

MeSH terms

  • DNA / chemistry*
  • Electrochemistry
  • Nucleic Acid Conformation*
  • Phosphates / chemistry
  • Thermodynamics

Substances

  • Phosphates
  • DNA