Vitamin B12 deficiency in infancy as a cause of developmental regression

Erasmo Barbante Casella; Marcelo Valente; Jessie Medeiros de Navarro; Fernando Kok

doi:10.1016/j.braindev.2005.02.005

Vitamin B12 deficiency in infancy as a cause of developmental regression

Brain Dev. 2005 Dec;27(8):592-4. doi: 10.1016/j.braindev.2005.02.005.

Authors

Erasmo Barbante Casella¹, Marcelo Valente, Jessie Medeiros de Navarro, Fernando Kok

Affiliation

¹ Child Neurology Unit, Pediatric Department, University of São Paulo Medical School, São Paulo, Brazil. [email protected]

PMID: 16310594
DOI: 10.1016/j.braindev.2005.02.005

Abstract

Vitamin B12 deficiency can cause serious developmental regression, hypotonia and cerebral atrophy in infants. We report a 6-month-old infant, with insidious developmental regression and brain atrophy showed by CT scan, secondarily to vitamin B12 deficiency. His mother was a strict vegetarian and the patient was exclusively breastfed. The clinical symptoms and the brain CT were normalized after vitamin B12 administration.

Publication types

Case Reports

MeSH terms

Atrophy
Brain / diagnostic imaging
Brain / pathology
Breast Feeding
Developmental Disabilities / etiology*
Diet, Vegetarian / adverse effects*
Humans
Infant
Male
Muscle Hypotonia / etiology
Radiography
Vitamin B 12 / therapeutic use
Vitamin B 12 Deficiency / complications*
Vitamin B 12 Deficiency / drug therapy

Substances

Vitamin B 12