Total synthesis, NMR solution structure, and binding model of the potent histone deacetylase inhibitor FR235222

Angew Chem Int Ed Engl. 2006 Jan 9;45(3):423-7. doi: 10.1002/anie.200501995.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Histone Deacetylase Inhibitors*
  • Histone Deacetylases / chemistry
  • Magnetic Resonance Spectroscopy / methods*
  • Models, Chemical*
  • Molecular Conformation
  • Peptides, Cyclic / chemical synthesis*
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / pharmacology
  • Protein Structure, Tertiary
  • Sensitivity and Specificity
  • Solutions / chemistry
  • Stereoisomerism
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • FR 235222
  • Histone Deacetylase Inhibitors
  • Peptides, Cyclic
  • Solutions
  • Histone Deacetylases