Abstract
Although statin drugs can have adverse effects on muscles and the liver, these effects are uncommon. Caution is warranted in patients at higher risk, ie, those who are elderly, frail, or small; have multisystem disease; are receiving immunosuppressive drugs or other medications that interact with statins; or are receiving higher doses of a statin.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alanine Transaminase / blood
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Animals
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Aspartate Aminotransferases / blood
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C-Reactive Protein / metabolism
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Chemical and Drug Induced Liver Injury
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Hypercholesterolemia / drug therapy
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Liver / drug effects*
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Liver / enzymology
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Liver Diseases / enzymology
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Lovastatin / adverse effects*
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Lovastatin / therapeutic use
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Muscle, Skeletal / drug effects*
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Muscle, Skeletal / enzymology
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Rhabdomyolysis / blood
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Rhabdomyolysis / chemically induced
Substances
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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C-Reactive Protein
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Lovastatin
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Aspartate Aminotransferases
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Alanine Transaminase