Abstract
Bone markers are aimed to assess bone cells activity. Some are specific of bone formation (osteocalcin, bone alkaline phosphatase, extension peptides of type I procollagen); others are specific of bone resorption (deoxypyridinoline and peptidebound forms.). Their main applications are: evaluation of fracture risk and follow-up of antiosteoporotic treatments. Their use in clinical practice is difficult: choice of the most appropriate bone marker, relevance of changes, and may require the specialist's opinion.
MeSH terms
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Acid Phosphatase / analysis
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Acid Phosphatase / metabolism
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Alkaline Phosphatase / analysis
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Alkaline Phosphatase / metabolism
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Biomarkers / analysis*
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Biomarkers / metabolism
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Bone Remodeling / physiology*
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Bone Resorption / diagnosis
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Bone Resorption / therapy
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Collagen / analysis
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Collagen / metabolism
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Collagen Type I
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Female
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Fractures, Bone / epidemiology
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Fractures, Bone / etiology
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Humans
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Menopause
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Osteocalcin / analysis
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Osteocalcin / metabolism
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Osteoporosis / complications
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Osteoporosis / diagnosis*
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Osteoporosis / therapy
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Peptides / analysis
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Peptides / metabolism
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Risk Factors
Substances
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Biomarkers
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Collagen Type I
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Peptides
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collagen type I trimeric cross-linked peptide
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Osteocalcin
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Collagen
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Alkaline Phosphatase
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Acid Phosphatase