Fetal cells in a transcervical cell sample collected at 5 weeks of gestation

Riccardo Cioni; Cecilia Bussani; Sandra Bucciantini; Gianfranco Scarselli

doi:10.1080/14767050500246391

Fetal cells in a transcervical cell sample collected at 5 weeks of gestation

J Matern Fetal Neonatal Med. 2005 Oct;18(4):271-3. doi: 10.1080/14767050500246391.

Authors

Riccardo Cioni¹, Cecilia Bussani, Sandra Bucciantini, Gianfranco Scarselli

Affiliation

¹ Department of Gynecology, Perinatology and Human Reproduction, University of Florence, Careggi University Hospital, Florence, Italy.

PMID: 16318979
DOI: 10.1080/14767050500246391

Abstract

Transcervical cell (TCC) sampling is being investigated as a promising method for obtaining fetal cells for prenatal genetic diagnosis. The present case report describes the identification of fetal cells by both fluorescent in situ hybridisation (FISH) and quantitative fluorescent polymerase chain reaction (QF-PCR) analyses in a TCC sample collected by intrauterine lavage at 5 + 0 weeks. This finding underscores the possible relevance of TCC sampling for extremely early prenatal genetic diagnosis.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Female
Fetus / cytology*
Fluorescence
Genetic Testing*
Gestational Age
Humans
In Situ Hybridization, Fluorescence
Placenta / cytology
Polymerase Chain Reaction / methods
Pregnancy
Prenatal Diagnosis / methods*
Sex Determination Processes
Therapeutic Irrigation*
Uterus / cytology*