Abstract
[chemical reaction: see text]. An expedient synthesis of (-)-pochonin A is reported (seven steps). This natural product is closely related to radicicol and was shown to be a 90 nM inhibitor of HSP90.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adenosine Triphosphatases / antagonists & inhibitors
-
Adenosine Triphosphate / antagonists & inhibitors
-
DNA Helicases / antagonists & inhibitors
-
HSP90 Heat-Shock Proteins / antagonists & inhibitors*
-
Lactones / chemical synthesis*
-
Lactones / chemistry
-
Lactones / pharmacology*
-
Macrolides / chemical synthesis*
-
Macrolides / chemistry
-
Macrolides / pharmacology*
-
Molecular Structure
-
Stereoisomerism
-
Structure-Activity Relationship
Substances
-
HSP90 Heat-Shock Proteins
-
Lactones
-
Macrolides
-
pochonin A
-
Adenosine Triphosphate
-
Adenosine Triphosphatases
-
DNA Helicases
-
monorden