Abstract
In this study, the complete DNA sequence of Shiga toxin 1-converting bacteriophage BP-4795 was determined. The genome of BP-4795 consists of 85 open reading frames, including two complete IS629 elements and three morons at the end of its late regulatory region. One of these morons encodes a type III effector that is translocated by the locus of enterocyte effacement-encoded type III secretion system into HeLa cells, where it localizes with the Golgi apparatus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Coliphages / genetics*
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DNA Transposable Elements
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Genome, Viral*
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Golgi Apparatus / chemistry
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HeLa Cells
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Humans
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Molecular Sequence Data
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Open Reading Frames
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Protein Transport
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Sequence Analysis, DNA
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Siphoviridae / genetics*
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Viral Proteins / analysis
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Viral Proteins / genetics*
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Viral Proteins / metabolism
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Virulence Factors / analysis
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Virulence Factors / genetics*
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Virulence Factors / metabolism
Substances
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DNA Transposable Elements
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Viral Proteins
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Virulence Factors