Abstract
Sequencing studies of the glycoprotein G gene were performed in human respiratory syncytial virus (hRSV) strains detected by reverse-transcription polymerase chain reaction directly from nasopharyngeal aspirates of hospitalized children < or =3 years old over 2 winters. Clinical data were compared between 106 children infected with group A hRSV (96 GA2 genotypes) and 94 children infected with hRSV group B (62 GB3 genotypes). A severity index was defined by assigning 1 point each for the use of >30% supplemental oxygen, admission to an intensive-care unit, and duration of hospital stay of >5 days. Group A and genotype GA2 strains were associated with greater severity of hRSV disease than were group B strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Child, Preschool
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Female
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Genotype
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Hospitalization*
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Humans
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Infant
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Infant, Newborn
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Infant, Premature, Diseases / epidemiology*
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Infant, Premature, Diseases / physiopathology
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Infant, Premature, Diseases / virology
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Male
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Respiratory Syncytial Virus Infections / epidemiology*
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Respiratory Syncytial Virus Infections / physiopathology
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Respiratory Syncytial Virus Infections / virology
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Respiratory Syncytial Virus, Human / classification
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Respiratory Syncytial Virus, Human / genetics
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Respiratory Syncytial Virus, Human / pathogenicity
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Seasons
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Sequence Analysis, DNA
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Severity of Illness Index*
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Viral Fusion Proteins / genetics
Substances
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G glycoprotein, Respiratory syncytial virus
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Viral Fusion Proteins