Abstract
Apigenin 7-O-beta-D-glucopyranuronide (1), luteolin 7-O-beta-D-glucopyranuronide (2), m-hydroxybenzyl beta-D-glucoside (3), and chrysoeriol 7-O-beta-D-glucopyranuronide (4) were isolated for the first time from the leaves of Salix matsudana. Furthermore, the effects of compounds 1, 2 and 3 on arachidonic acid metabolism were studied. These compounds inhibited significantly the production of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE). In addition, the aglycon apigenin inhibited not only 12-HETE but also thromboxane B(2) (TXB(2)). The effect of compound (4) on arachidonic acid metabolism is now under investigation.
MeSH terms
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12-Hydroxy-5,8,10,14-eicosatetraenoic Acid / metabolism
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Animals
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Apigenin / isolation & purification
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Apigenin / pharmacology*
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Arachidonic Acid / metabolism*
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Blood Platelets / metabolism*
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Cells, Cultured
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Depression, Chemical
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Flavones
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Flavonoids / isolation & purification
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Flavonoids / pharmacology
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Glucosides / isolation & purification
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Glucosides / pharmacology*
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Luteolin / isolation & purification
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Luteolin / pharmacology*
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Male
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Plant Leaves / chemistry*
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Rats
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Rats, Wistar
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Salix / chemistry*
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Structure-Activity Relationship
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Thromboxane B2 / metabolism
Substances
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Flavones
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Flavonoids
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Glucosides
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Arachidonic Acid
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Thromboxane B2
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12-Hydroxy-5,8,10,14-eicosatetraenoic Acid
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apigetrin
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Apigenin
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luteolin-7-glucoside
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Luteolin
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chrysoeriol