Minor histocompatibility antigen HA-8 mismatch and clinical outcome after HLA-identical sibling donor allogeneic stem cell transplantation

Haematologica. 2005 Dec;90(12):1723-4.

Abstract

We analyzed the clinical outcome of 146 adult patients receiving an HLA-identical sibling donor stem cell transplant depending on HA-8 matching status. The presence of an HA-8 mismatch was associated with an increased risk of severe acute graft-versus-host disease and with a worse overall survival.

Publication types

  • Comparative Study
  • Letter

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Anemia, Aplastic / mortality
  • Anemia, Aplastic / surgery
  • Disease-Free Survival
  • Female
  • Graft vs Host Disease / etiology*
  • Graft vs Host Disease / mortality
  • HLA Antigens / immunology
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Histocompatibility*
  • Humans
  • Life Tables
  • Living Donors
  • Male
  • Middle Aged
  • Minor Histocompatibility Antigens / immunology*
  • Neoplasms / mortality
  • Neoplasms / surgery
  • Proportional Hazards Models
  • Retrospective Studies
  • Severity of Illness Index
  • Siblings
  • Survival Analysis
  • Transplantation Conditioning
  • Transplantation, Homologous / adverse effects*
  • Treatment Outcome

Substances

  • HLA Antigens
  • Minor Histocompatibility Antigens
  • PUM3 protein, human