Abstract
D-Factor (differentiation-inducing factor or leukemia inhibitory factor) and growth hormone are proteins that regulate growth and differentiation of cells. In this study, we demonstrated that recombinant human D-factor and growth hormone caused a slight but significant protection of adult rats against oxygen toxicity without affecting levels of pulmonary manganous superoxide dismutase (MnSOD) mRNA. D-Factor and growth hormone also markedly enhanced tumor necrosis factor (TNF)-induced oxygen tolerance. This latter effect was associated with a marked enhancement of TNF-mediated induction of pulmonary MnSOD mRNA.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Drug Synergism
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Drug Tolerance / genetics
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Growth Hormone / pharmacology*
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Growth Inhibitors / pharmacology*
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Insufflation
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Interleukin-6*
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Leukemia Inhibitory Factor
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Lung / metabolism
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Lymphokines / pharmacology*
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Oxygen / toxicity*
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RNA, Messenger / metabolism*
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Rats
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Superoxide Dismutase / genetics*
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Survival Rate
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Trachea
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Tumor Necrosis Factor-alpha / pharmacology*
Substances
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Growth Inhibitors
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Interleukin-6
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LIF protein, human
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Leukemia Inhibitory Factor
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Lymphokines
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RNA, Messenger
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Tumor Necrosis Factor-alpha
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Growth Hormone
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Superoxide Dismutase
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Oxygen