Increase in activity during calorie restriction requires Sirt1

Science. 2005 Dec 9;310(5754):1641. doi: 10.1126/science.1118357.

Abstract

Sir2 (silent information regulator 2) is a nicotinamide adenine dinucleotide-dependent deacetylase required for longevity due to calorie restriction in yeast and Drosophila. In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Caloric Restriction*
  • Eating
  • Mice
  • Mice, Knockout
  • Motor Activity*
  • Movement
  • Sirtuin 1
  • Sirtuins / genetics
  • Sirtuins / physiology*

Substances

  • Sirt1 protein, mouse
  • Sirtuin 1
  • Sirtuins