Abstract
To investigate the effect of cyclosporine A (Cyc A) on the development of fibroadenomas, 30 renal transplant patients and 20 chronic renal failure patients on dialysis were breast examined with ultrasonography and/or mammography. Of the renal transplant patients, 17 were receiving Cyc A-based combination therapy for immunosuppression. All patients were female with the age range of 29.7+/-9.2 years in the transplant group and 33.95+/-9.91 in the dialysis group. Eight of the 17 patients receiving Cyc A had fibroadenomas, 5 of them having bilateral lesions. None of the other patients, those on dialysis and on non-Cyc A combination therapy had fibroadenomas. A significant difference for fibroadenoma incidence in patients receiving Cyc A combination immunosuppression was found.
MeSH terms
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Adult
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Biopsy, Needle
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Breast Neoplasms / chemically induced*
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Breast Neoplasms / epidemiology
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Breast Neoplasms / pathology
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Cross-Sectional Studies
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Cyclosporine / adverse effects*
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Cyclosporine / therapeutic use
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Female
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Fibroadenoma / chemically induced*
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Fibroadenoma / epidemiology
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Fibroadenoma / pathology
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Follow-Up Studies
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Humans
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Immunohistochemistry
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Immunosuppressive Agents / adverse effects*
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Immunosuppressive Agents / therapeutic use
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Incidence
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Kidney Failure, Chronic / diagnosis
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Kidney Failure, Chronic / therapy
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Kidney Transplantation / adverse effects
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Kidney Transplantation / immunology*
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Kidney Transplantation / methods
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Renal Dialysis / adverse effects
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Renal Dialysis / methods
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Risk Assessment
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Transplantation Immunology / physiology
Substances
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Immunosuppressive Agents
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Cyclosporine