Self-assembling a molecular pegboard

Kyle Lund; Yan Liu; Stuart Lindsay; Hao Yan

doi:10.1021/ja0568446

Self-assembling a molecular pegboard

J Am Chem Soc. 2005 Dec 21;127(50):17606-7. doi: 10.1021/ja0568446.

Authors

Kyle Lund¹, Yan Liu, Stuart Lindsay, Hao Yan

Affiliation

¹ Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, USA.

PMID: 16351081
DOI: 10.1021/ja0568446

Abstract

This paper describes the design, construction, and application of a self-assembled, chemically addressable DNA nanogrid composed of DNA tiles of nanometer dimensions. This self-assembled structure permits precise placement of molecules at predetermined locations on a "molecular pegboard". We used the indexed DNA nanogrids to identify single molecules of DNA that hybridize at particular locations.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

DNA / chemical synthesis
DNA / chemistry*
Microarray Analysis
Microscopy, Atomic Force
Models, Molecular
Nanostructures / chemistry*
Nucleic Acid Conformation
Nucleic Acid Hybridization
Streptavidin / chemistry

Substances

DNA
Streptavidin