Cyclooxygenase-1 and cyclooxygenase-2 inhibition of novel 1,2-disubstituted imidazoles

Arch Pharm (Weinheim). 2005 Dec;338(12):602-4. doi: 10.1002/ardp.200500178.

Abstract

Novel 1,2-disubstituted imidazoles were synthesized and tested for COX-1 and COX-2 inhibition. A substituted phenyl cycle in position 1 and an alicyclic tertiary alcohol in position 2 gave COX-1-selective compounds with potency and selectivity depending on the different substituents.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cyclooxygenase 1 / metabolism*
  • Cyclooxygenase 2 / metabolism*
  • Cyclooxygenase 2 Inhibitors / chemical synthesis
  • Cyclooxygenase 2 Inhibitors / pharmacology
  • Cyclooxygenase Inhibitors / chemical synthesis*
  • Cyclooxygenase Inhibitors / pharmacology
  • Dose-Response Relationship, Drug
  • Humans
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology
  • Inhibitory Concentration 50
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / metabolism
  • Structure-Activity Relationship

Substances

  • Cyclooxygenase 2 Inhibitors
  • Cyclooxygenase Inhibitors
  • Imidazoles
  • Isoenzymes
  • Cyclooxygenase 1
  • Cyclooxygenase 2