Voriconazole in the treatment of fungal osteomyelitis of the orbit in the immunocompromised host

Orbit. 2005 Dec;24(4):285-9. doi: 10.1080/01676830500187696.

Abstract

Scedosporium apiospermum is an uncommon cause of fungal infection in the orbit and sinus. Morbidity and mortality rates in immunocompromised patients are high. We review the first case of Scedosporium apiospermum orbito-sinus infection that was successfully treated with the new antifungal agent voriconazole. We highlight the efficacy of this drug, particularly in the treatment of osteomyelitis of the orbit and sinus, which may lead to an improvement in survival rates after Scedosporium infection.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antifungal Agents / therapeutic use*
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunocompromised Host*
  • Magnetic Resonance Imaging
  • Mycetoma / diagnosis
  • Mycetoma / drug therapy*
  • Orbital Diseases / diagnosis
  • Orbital Diseases / drug therapy*
  • Orbital Diseases / microbiology*
  • Osteomyelitis / diagnosis
  • Osteomyelitis / drug therapy*
  • Osteomyelitis / microbiology*
  • Pyrimidines / therapeutic use*
  • Scedosporium / isolation & purification*
  • Tomography, X-Ray Computed
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole