Abstract
A series of triazino tetrahydroisoquinolines (3-5) and beta-carboline derivatives (15-27) have been synthesized as novel antileishmanial agents. Among them, compounds 15, 16 and 25 have shown 78.0%, 78.6% and 68.0% in vivo inhibition against Leishmania donovani at a dose of 50 mg kg(-1) x 5 days, respectively, while compounds 3 and 18 exhibited 55.6% and 53.3% in vivo inhibitions, respectively, against L. donovani at a dose of 50 mg kg(-1) x 5 days.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / chemical synthesis*
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Antiprotozoal Agents / chemistry
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Antiprotozoal Agents / pharmacology
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Carbolines / chemical synthesis*
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Carbolines / chemistry
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Carbolines / pharmacology
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Cricetinae
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Inhibitory Concentration 50
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Leishmania donovani / drug effects*
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Mesocricetus
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Molecular Structure
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Parasitic Sensitivity Tests
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Structure-Activity Relationship
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Tetrahydroisoquinolines / chemical synthesis*
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Tetrahydroisoquinolines / chemistry
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Tetrahydroisoquinolines / pharmacology
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Triazines / chemistry*
Substances
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Antiprotozoal Agents
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Carbolines
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Tetrahydroisoquinolines
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Triazines