Abstract
Musashi-1 is involved in maintenance of neural stem cells. In the rat stomach, we found some cells in the luminal compartment of the mucosa that stained positively for Musashi-1. These cells were distinct from other cells of epithelial lineage, except for parietal cells, and coexpressed HES5. The Musashi-1-positive cells exfoliated after damage, while Musashi-1 expression in neck cells were upregulated, and proliferating cells diminished before reappearing and increasing in number thereafter. We conclude that a subpopulation of parietal cells acts as a source of Musashi-1, which contributes to rapid re-epithelization by restoration of stem cells and regulation of cell differentiation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Basic Helix-Loop-Helix Transcription Factors / biosynthesis
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Cell Differentiation / physiology
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Epithelium / metabolism
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Gene Expression Regulation / physiology*
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Male
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Nerve Tissue / cytology
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Nerve Tissue / metabolism*
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Nerve Tissue Proteins / biosynthesis*
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Parietal Cells, Gastric / cytology
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Parietal Cells, Gastric / metabolism*
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RNA-Binding Proteins / biosynthesis*
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Rats
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Rats, Wistar
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Regeneration / physiology*
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Repressor Proteins / biosynthesis
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Stem Cells / cytology
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Stem Cells / metabolism*
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Hes5 protein, rat
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Msi1 protein, rat
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Nerve Tissue Proteins
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RNA-Binding Proteins
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Repressor Proteins