Abstract
Several calmodulin antagonists, W-7, amitriptyline, trifluoperazine, chlorpromazine, dibucaine, prenylamine, calmidazolium, and compound 48/80, inhibited lipid peroxidation induced non-enzymatically in rat brain homogenate by ascorbate and Fe2+. Suggestions of involvement of calmodulin in various oxidative cellular responses, based on experiments using calmodulin antagonists, may need to be re-evaluated.
MeSH terms
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Animals
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Antioxidants / pharmacology*
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Brain Chemistry / drug effects*
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Calmodulin / antagonists & inhibitors*
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Imidazoles / pharmacology
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Lipid Peroxidation / drug effects
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Male
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Phenothiazines / pharmacology
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Rats
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Rats, Inbred Strains
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Subcellular Fractions / drug effects
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Sulfonamides / pharmacology
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p-Methoxy-N-methylphenethylamine / pharmacology
Substances
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Antioxidants
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Calmodulin
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Imidazoles
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Phenothiazines
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Sulfonamides
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p-Methoxy-N-methylphenethylamine
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calmidazolium
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W 7
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phenothiazine