Stimulation on DNA triplet repeat strand slippage synthesis by the designed spirocycles

Zhen Xi; Di Ouyang; Hong-Tao Mu

doi:10.1016/j.bmcl.2005.11.082

Stimulation on DNA triplet repeat strand slippage synthesis by the designed spirocycles

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1180-4. doi: 10.1016/j.bmcl.2005.11.082. Epub 2005 Dec 20.

Authors

Zhen Xi¹, Di Ouyang, Hong-Tao Mu

Affiliation

¹ State Key Laboratory of Elemento-Organic Chemistry, Department of Chemical Biology, Nankai University, Tianjin 300071, China. [email protected]

PMID: 16364637
DOI: 10.1016/j.bmcl.2005.11.082

Abstract

The designed simpler chiral spirocyclic helical compounds that mimic the molecular architecture of the DNA bulge binder NCSi-gb have been prepared. It has been found that the synthesized spirocyclic compounds have strong stimulation effect on DNA slippage synthesis. Their stimulation activities on DNA strand slippage suggest that they may bind to or induce the formation of a non Watson-Crick structure during in vitro replication of DNA triplet repeats.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Carbohydrates / chemistry
Cyclization
DNA / biosynthesis*
DNA / chemistry
DNA / genetics*
DNA Replication / drug effects*
DNA-Directed DNA Polymerase / metabolism
Molecular Structure
Nucleic Acid Conformation
Stereoisomerism
Stimulation, Chemical
Trinucleotide Repeats / genetics*

Substances

Carbohydrates
DNA
DNA-Directed DNA Polymerase