To think or not to think: synaptic activity and Abeta release

Brock E Schroeder; Edward H Koo

doi:10.1016/j.neuron.2005.12.005

To think or not to think: synaptic activity and Abeta release

Neuron. 2005 Dec 22;48(6):873-5. doi: 10.1016/j.neuron.2005.12.005.

Authors

Brock E Schroeder¹, Edward H Koo

Affiliation

¹ Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA.

PMID: 16364890
DOI: 10.1016/j.neuron.2005.12.005

Abstract

Accumulation of beta-amyloid protein (Abeta) in the extracellular space of the brain has been hypothesized to be a culprit in the pathogenesis of Alzheimer's disease. In this issue of Neuron, Cirrito et al. describe a series of experiments demonstrating that extracellular Abeta levels are directly modulated by neuronal and synaptic activity.

Publication types

Review
Comment

MeSH terms

Alzheimer Disease / metabolism*
Alzheimer Disease / physiopathology
Amyloid Precursor Protein Secretases
Amyloid beta-Peptides / metabolism*
Animals
Aspartic Acid Endopeptidases
Brain / metabolism*
Brain / physiopathology
Endopeptidases / metabolism
Extracellular Fluid / metabolism
Humans
Plaque, Amyloid / metabolism
Presynaptic Terminals / metabolism*
Synaptic Transmission / physiology*
Synaptic Vesicles / metabolism

Substances

Amyloid beta-Peptides
Amyloid Precursor Protein Secretases
Endopeptidases
Aspartic Acid Endopeptidases
BACE1 protein, human