Abstract
Microspheres (MS) conjugated to Porphyromonas gingivalis vesicles with type II fimbriae were the most efficient human epithelial cell invaders among the six types. Cell death was induced by MS, though becoming less frequent over time, with invasion efficiency partially related to cell death and gingipains likely the major cause.
MeSH terms
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Adhesins, Bacterial / metabolism
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Apoptosis* / physiology
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Bacteroidaceae Infections / microbiology
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Bacteroidaceae Infections / pathology
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Cell Wall / physiology
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Cells, Cultured
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Cysteine Endopeptidases / metabolism
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Epithelial Cells / microbiology*
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Epithelial Cells / pathology*
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Fimbriae, Bacterial / physiology*
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Gingipain Cysteine Endopeptidases
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HeLa Cells
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Humans
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Microspheres*
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Porphyromonas gingivalis / physiology*
Substances
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Adhesins, Bacterial
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Gingipain Cysteine Endopeptidases
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Cysteine Endopeptidases