Photochemical tools for remote control of ion channels in excitable cells

Nat Chem Biol. 2005 Dec;1(7):360-5. doi: 10.1038/nchembio750.

Abstract

Various strategies have been developed recently for imparting light sensitivity onto normally insensitive cells. These include expression of natural photosensitive proteins, photolysis of caged agonists of native cell surface receptors and photoswitching of isomerizable tethered ligands that act on specially engineered ion channels and receptor targets. The development of chemical tools for optically stimulating or inhibiting signaling proteins has particular relevance for the nervous system, where precise, noninvasive control is an experimental and medical necessity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Membrane* / metabolism
  • Cell Membrane* / radiation effects
  • Ion Channels* / metabolism
  • Ion Channels* / radiation effects
  • Iron / metabolism*
  • Models, Biological
  • Molecular Structure
  • Photochemistry
  • Time Factors

Substances

  • Ion Channels
  • Iron