Molecular targets of indirubins

Int J Clin Pharmacol Ther. 2005 Dec;43(12):592-4. doi: 10.5414/cpp43592.
No abstract available

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Apoptosis
  • CSK Tyrosine-Protein Kinase
  • Cell Line, Tumor
  • Cyclin-Dependent Kinases / antagonists & inhibitors*
  • Cyclin-Dependent Kinases / metabolism
  • Cyclins / antagonists & inhibitors
  • Cyclins / metabolism
  • Drug Screening Assays, Antitumor
  • Humans
  • Indoles / chemistry
  • Indoles / pharmacology*
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins / antagonists & inhibitors
  • Microtubule-Associated Proteins / metabolism
  • Monosaccharides / pharmacology*
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Neoplasm Proteins / antagonists & inhibitors
  • Neoplasm Proteins / metabolism
  • Oximes
  • Phosphorylation
  • Protein Kinase Inhibitors / chemistry
  • Protein-Tyrosine Kinases / antagonists & inhibitors
  • Protein-Tyrosine Kinases / metabolism
  • Proto-Oncogene Proteins / antagonists & inhibitors
  • Proto-Oncogene Proteins / metabolism
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors
  • Proto-Oncogene Proteins c-bcl-2 / metabolism
  • Retinoblastoma Protein / metabolism
  • STAT3 Transcription Factor / antagonists & inhibitors
  • STAT3 Transcription Factor / metabolism
  • Survivin
  • src-Family Kinases

Substances

  • Antineoplastic Agents
  • BIRC5 protein, human
  • Cyclins
  • E671 bisindole
  • E729 bisindole
  • Indirubin E804
  • Indoles
  • Inhibitor of Apoptosis Proteins
  • Microtubule-Associated Proteins
  • Monosaccharides
  • Myeloid Cell Leukemia Sequence 1 Protein
  • Neoplasm Proteins
  • Oximes
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Retinoblastoma Protein
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • Survivin
  • Protein-Tyrosine Kinases
  • CSK Tyrosine-Protein Kinase
  • src-Family Kinases
  • CSK protein, human
  • Cyclin-Dependent Kinases
  • indirubin